Pre-clinical Evaluation Module
This module serves as the first link between formulation work and translational research. In this module, researchers are provided with the capability to assess their nanomedicine under biological conditions. The NanoMed Fab is equipped with a biosafety level 2 (BSL-2) laboratory containing all necessary equipment, such as biosafety cabinets (BSCs), cell incubators, biological fridge and freezer, as well as a cryopreservation unit. Users can take advantage of this research area to evaluate several important performance parameters of their nanomedicine formulations, including in vitro therapeutic efficacy, target affinity and specificity, luminescence and fluorescence behavior, etc.
General Applications
- Evaluation of target binding specificity, affinity and kinetics
- Evaluation of gene expression or gene knock down level
- Visualization of cell-binding, tissue slides, etc.
- Evaluation of luminescence
- Evaluation of absorbance/fluorescence, kinetics, FRET, etc.
- Tissue/cell disruption, lysis and homogenization
- Cell fractionation, cellular component extraction
- Temperature controlled sample incubation/shaking
- MultiTherm™ shaker
- Isotemp™ Lab Oven (vendor link)
- Biological work
- Labculture® Class II, Type A2 Biological Safety Cabinets (2x) (vendor link)
- Heracell™ 150i and 240i Carbon Dioxide Incubators (2x) (vendor link)
- Locator™ Plus Rack and Box Cryopreservation System (vendor link)
- Fridge and freezer for biological materials such as serum, media, buffer, etc.
- Other general equipment
- Centrifuge, pH meter
